6FV9

Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-007

Summary for 6FV9

Related6FDI 6FDS 6FDW 6FDX 6FE3 6FE7 6FEB 6FET
DescriptorPhosphodiesterase, MAGNESIUM ION, ZINC ION, ... (6 entities in total)
Functional Keywordsparasitic phosphodiesterase, hydrolase, african trypanosomiasis, sleeping sickness
Biological sourceTrypanosoma brucei
Total number of polymer chains2
Total molecular weight82811.62
Authors
Singh, A.K.,Brown, D.G. (deposition date: 2018-03-01, release date: 2019-03-20)
Primary citation
Salado, I.G.,Moreno, C.,Sakaine, G.,Singh, A.K.,Blaazer, A.R.,Siderius, M.,Matheeussen, A.,Gul, S.,Maes, L.,Leurs, R.,Brown, D.G.,Augustyns, K.
TbrPDEB1 structure with inhibitor NPD-007
To be published,
Experimental method
X-RAY DIFFRACTION (2.48 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2572 0.3% 2.8% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6fv9
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Molmil generated image of 6fv9
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Molmil generated image of 6fv9
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 6fv9
no rotation
Molmil generated image of 6fv9
rotated about x axis by 90°
Molmil generated image of 6fv9
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6fv9.pdb1.gz [60.5 KB])
Coordinate files for Biological unit (6fv9.pdb2.gz [59.59 KB])