6FRD

Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-637

Summary for 6FRD

DescriptorPhosphodiesterase, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordsparasitic phosphodiesterase, hydrolase, african trypanosomiasis, sleeping sickness
Biological sourceTrypanosoma brucei
Total number of polymer chains2
Total molecular weight82382.22
Authors
Singh, A.K.,Brown, D.G. (deposition date: 2018-02-15, release date: 2019-03-13)
Primary citation
Singh, A.K.,Brown, D.G.
Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-637
To be published,
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2152 0.3% 3.7% 3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6frd
no rotation
Molmil generated image of 6frd
rotated about x axis by 90°
Molmil generated image of 6frd
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 6frd
no rotation
Molmil generated image of 6frd
rotated about x axis by 90°
Molmil generated image of 6frd
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6frd.pdb2.gz [58.52 KB])
Coordinate files for Biological unit (6frd.pdb1.gz [58.16 KB])