6FOX

The crystal structure of P.fluorescens Kynurenine 3-monooxygenase (KMO) in complex with kynurenine

Summary for 6FOX

Entry DOI	10.2210/pdb6fox/pdb
Descriptor	Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CALCIUM ION, ... (5 entities in total)
Functional Keywords	substrate, oxidoreductase
Biological source	Pseudomonas fluorescens
Total number of polymer chains	2
Total formula weight	103036.04
Authors	Levy, C.W.,Leys, D. (deposition date: 2018-02-08, release date: 2019-08-21, Last modification date: 2020-03-04)
Primary citation	Zhang, S.,Sakuma, M.,Deora, G.S.,Levy, C.W.,Klausing, A.,Breda, C.,Read, K.D.,Edlin, C.D.,Ross, B.P.,Wright Muelas, M.,Day, P.J.,O'Hagan, S.,Kell, D.B.,Schwarcz, R.,Leys, D.,Heyes, D.J.,Giorgini, F.,Scrutton, N.S. A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites. Commun Biol, 2:271-271, 2019 Cited by PubMed: 31372510 DOI: 10.1038/s42003-019-0520-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation