6FNE

Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain

Summary for 6FNE

• Entry DOI: 10.2210/pdb6fne/pdb
• Descriptor: IQ motif and SEC7 domain-containing protein 1, (2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one, NONAETHYLENE GLYCOL, ... (4 entities in total)
• Functional Keywords: arf gef, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 95474.78

Authors

Nawrotek, A.,Zeghouf, M.,Cherfils, J. (deposition date: 2018-02-03, release date: 2019-03-13, Last modification date: 2024-01-17)

• Primary citation: Nawrotek, A.,Benabdi, S.,Niyomchon, S.,Kryszke, M.H.,Ginestier, C.,Caneque, T.,Tepshi, L.,Mariani, A.,St Onge, R.P.,Giaever, G.,Nislow, C.,Charafe-Jauffret, E.,Rodriguez, R.,Zeghouf, M.,Cherfils, J.; PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.; Nat.Chem.Biol., 15:358-366, 2019; PubMed: 30742123; DOI: 10.1038/s41589-019-0228-3

Experimental method

X-RAY DIFFRACTION (2.501 Å)