6FMC

Neuropilin1-b1 domain in complex with EG01377, 0.9 Angstrom structure

Summary for 6FMC

Entry DOI	10.2210/pdb6fmc/pdb
Descriptor	Neuropilin-1, (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid (3 entities in total)
Functional Keywords	vegf-receptor, semaphorin-receptor, small molecule inhibitor, angiogenesis, discoidin domain, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18501.96
Authors	Yelland, T.,Djordjevic, S.,Fotinou, K.,Selwood, D.,Zachary, I.,Frankel, P. (deposition date: 2018-01-30, release date: 2018-10-17, Last modification date: 2024-01-17)
Primary citation	Powell, J.,Mota, F.,Steadman, D.,Soudy, C.,Miyauchi, J.T.,Crosby, S.,Jarvis, A.,Reisinger, T.,Winfield, N.,Evans, G.,Finniear, A.,Yelland, T.,Chou, Y.T.,Chan, A.W.E.,O'Leary, A.,Cheng, L.,Liu, D.,Fotinou, C.,Milagre, C.,Martin, J.F.,Jia, H.,Frankel, P.,Djordjevic, S.,Tsirka, S.E.,Zachary, I.C.,Selwood, D.L. Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells. J. Med. Chem., 61:4135-4154, 2018 Cited by PubMed: 29648813 DOI: 10.1021/acs.jmedchem.8b00210 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.9 Å)

Structure validation