6FIB

Structure of human 4-1BB ligand

Summary for 6FIB

• Entry DOI: 10.2210/pdb6fib/pdb
• Descriptor: Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor ligand superfamily member 9,4-1BBL -CH/CL fusion, Tumor necrosis factor ligand superfamily member 9,Uncharacterized protein, ... (4 entities in total)
• Functional Keywords: cytokine, signal anchor, tnf family
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 82496.89

Authors

Joseph, C.,Claus, C.,Ferrara, C.,von Hirschheydt, T.,Prince, C.,Funk, D.,Klein, C.,Benz, J. (deposition date: 2018-01-17, release date: 2019-03-13, Last modification date: 2024-01-17)

• Primary citation: Claus, C.,Ferrara, C.,Xu, W.,Sam, J.,Lang, S.,Uhlenbrock, F.,Albrecht, R.,Herter, S.,Schlenker, R.,Husser, T.,Diggelmann, S.,Challier, J.,Mossner, E.,Hosse, R.J.,Hofer, T.,Brunker, P.,Joseph, C.,Benz, J.,Ringler, P.,Stahlberg, H.,Lauer, M.,Perro, M.,Chen, S.,Kuttel, C.,Bhavani Mohan, P.L.,Nicolini, V.,Birk, M.C.,Ongaro, A.,Prince, C.,Gianotti, R.,Dugan, G.,Whitlow, C.T.,Solingapuram Sai, K.K.,Caudell, D.L.,Burgos-Rodriguez, A.G.,Cline, J.M.,Hettich, M.,Ceppi, M.,Giusti, A.M.,Crameri, F.,Driessen, W.,Morcos, P.N.,Freimoser-Grundschober, A.,Levitsky, V.,Amann, M.,Grau-Richards, S.,von Hirschheydt, T.,Tournaviti, S.,Molhoj, M.,Fauti, T.,Heinzelmann-Schwarz, V.,Teichgraber, V.,Colombetti, S.,Bacac, M.,Zippelius, A.,Klein, C.,Umana, P.; Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.; Sci Transl Med, 11:-, 2019; PubMed: 31189721; DOI: 10.1126/scitranslmed.aav5989

Experimental method

X-RAY DIFFRACTION (2.7 Å)