6FDL

Crystal structure of the NYN domain of human MARF1

Summary for 6FDL

DescriptorMeiosis regulator and mRNA stability factor 1 (2 entities in total)
Functional Keywordsmrna turnover, decapping, deadenylation-independent decapping, nyn domain, ribonuclease, rna, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight36466.66
Authors
Jinek, M.,Brandmann, T. (deposition date: 2017-12-26, release date: 2018-11-07)
Primary citation
Nishimura, T.,Fakim, H.,Brandmann, T.,Youn, J.Y.,Gingras, A.C.,Jinek, M.,Fabian, M.R.
Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
Nucleic Acids Res., 2018
PubMed: 30364987 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gky1011
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22330 0.8% 6.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6fdl
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Molmil generated image of 6fdl
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Molmil generated image of 6fdl
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More Biological unit images

Molmil generated image of 6fdl
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Molmil generated image of 6fdl
rotated about x axis by 90°
Molmil generated image of 6fdl
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6fdl.pdb1.gz [54.98 KB])
Coordinate files for Biological unit (6fdl.pdb2.gz [53.45 KB])
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