6FDL
Crystal structure of the NYN domain of human MARF1
Summary for 6FDL
Entry DOI | 10.2210/pdb6fdl/pdb |
Descriptor | Meiosis regulator and mRNA stability factor 1 (2 entities in total) |
Functional Keywords | mrna turnover, decapping, deadenylation-independent decapping, nyn domain, ribonuclease, rna, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 36466.66 |
Authors | Jinek, M.,Brandmann, T. (deposition date: 2017-12-26, release date: 2018-11-07, Last modification date: 2018-12-26) |
Primary citation | Nishimura, T.,Fakim, H.,Brandmann, T.,Youn, J.Y.,Gingras, A.C.,Jinek, M.,Fabian, M.R. Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs. Nucleic Acids Res., 46:12008-12021, 2018 Cited by PubMed: 30364987DOI: 10.1093/nar/gky1011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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