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6FDL

Crystal structure of the NYN domain of human MARF1

Summary for 6FDL
Entry DOI10.2210/pdb6fdl/pdb
DescriptorMeiosis regulator and mRNA stability factor 1 (2 entities in total)
Functional Keywordsmrna turnover, decapping, deadenylation-independent decapping, nyn domain, ribonuclease, rna, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight36466.66
Authors
Jinek, M.,Brandmann, T. (deposition date: 2017-12-26, release date: 2018-11-07, Last modification date: 2018-12-26)
Primary citationNishimura, T.,Fakim, H.,Brandmann, T.,Youn, J.Y.,Gingras, A.C.,Jinek, M.,Fabian, M.R.
Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
Nucleic Acids Res., 46:12008-12021, 2018
Cited by
PubMed: 30364987
DOI: 10.1093/nar/gky1011
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.75 Å)
Structure validation

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