6FAZ

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the positive allosteric modulator TDPAM01 at 1.4 A resolution.

Summary for 6FAZ

Entry DOI	10.2210/pdb6faz/pdb
Descriptor	Glutamate receptor 2, SULFATE ION, DI(HYDROXYETHYL)ETHER, ... (10 entities in total)
Functional Keywords	ampa receptor, glua2, ligand-binding domain, glua2-s1s2j, positive allosteric modulator, membrane protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	2
Total formula weight	60905.80
Authors	Nielsen, L.,Laulumaa, S.,Kastrup, J.S. (deposition date: 2017-12-18, release date: 2018-11-21, Last modification date: 2024-01-17)
Primary citation	Drapier, T.,Geubelle, P.,Bouckaert, C.,Nielsen, L.,Laulumaa, S.,Goffin, E.,Dilly, S.,Francotte, P.,Hanson, J.,Pochet, L.,Kastrup, J.S.,Pirotte, B. Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds. J. Med. Chem., 61:5279-5291, 2018 Cited by PubMed: 29775064 DOI: 10.1021/acs.jmedchem.8b00250 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation