6F06

CATHEPSIN L IN COMPLEX WITH (3S,14E)-8-(azetidin-3-yl)-19-chloro-N-(1-cyanocyclopropyl)-5-oxo-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(21),6,8,10,14,18(22),19-heptaene-3-carboxamide

Summary for 6F06

Entry DOI	10.2210/pdb6f06/pdb
Related	6EZP 6EZX
Descriptor	Cathepsin L1, (3~{S},14~{E})-8-(azetidin-3-yl)-19-chloranyl-~{N}-(1-cyanocyclopropyl)-5-oxidanylidene-12,17-dioxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(21),6(11),7,9,14,18(22),19-heptaene-3-carboxamide, ZINC ION, ... (5 entities in total)
Functional Keywords	protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Lysosome: P07711
Total number of polymer chains	2
Total formula weight	50384.00
Authors	Kuglstatter, A.,Stihle, M. (deposition date: 2017-11-17, release date: 2018-04-11, Last modification date: 2018-05-09)
Primary citation	Giroud, M.,Dietzel, U.,Anselm, L.,Banner, D.,Kuglstatter, A.,Benz, J.,Blanc, J.B.,Gaufreteau, D.,Liu, H.,Lin, X.,Stich, A.,Kuhn, B.,Schuler, F.,Kaiser, M.,Brun, R.,Schirmeister, T.,Kisker, C.,Diederich, F.,Haap, W. Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors. J. Med. Chem., 61:3350-3369, 2018 Cited by PubMed: 29590750 DOI: 10.1021/acs.jmedchem.7b01869 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation