6EYJ

E-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic ligand NV354

Summary for 6EYJ

• Entry DOI: 10.2210/pdb6eyj/pdb
• Descriptor: E-selectin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2~{S})-3-cyclohexyl-2-[(2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-3,5-bis(oxidanyl)-6-[(1~{R},2~{R})-2-[(2~{R},3~{S},4~{R},5~{S},6~{R})-3,4,5-tris(oxidanyl)-6-(trifluoromethyl)oxan-2-yl]oxycyclohexyl]oxy-oxan-4-yl]oxy-propanoic acid, ... (5 entities in total)
• Functional Keywords: cell adhesion, cell-adhesion molecule, c-type lectin, inflammation, leukocyte, glycomimetic, catch-bond
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 67053.82

Authors

Jakob, R.P.,Zihlmann, P.,Preston, R.C.,Varga, N.,Ernst, B.,Maier, T. (deposition date: 2017-11-13, release date: 2018-11-21, Last modification date: 2024-01-17)

• Primary citation: Varga, N.,Zihlmann, P.,Preston, R.C.,Jakob, R.P.,Maier, T.,Ernst, B.; E-selectin lectin with different glycomimetic ligands; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)