6EUC

Reactivating oxime bound to Tc AChE's catalytic gorge.

Summary for 6EUC

• Entry DOI: 10.2210/pdb6euc/pdb
• Descriptor: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-[(~{E})-hydroxyiminomethyl]-6-(5-morpholin-4-ylpentyl)pyridin-3-ol, ... (5 entities in total)
• Functional Keywords: acetylcholinesterase, reactivator, aldehyde oxime, organophosphate poisoning, hydrolase
• Biological source: Tetronarce californica (Pacific electric ray)
• Total number of polymer chains: 1
• Total formula weight: 66987.41

Authors

de la Mora, E.,Weik, M.,Braiki, A.,Mougeot, R.,Jean, L.,Renard, P.I. (deposition date: 2017-10-30, release date: 2018-11-14, Last modification date: 2020-07-29)

• Primary citation: Zorbaz, T.,Braiki, A.,Marakovic, N.,Renou, J.,de la Mora, E.,Macek Hrvat, N.,Katalinic, M.,Silman, I.,Sussman, J.L.,Mercey, G.,Gomez, C.,Mougeot, R.,Perez, B.,Baati, R.,Nachon, F.,Weik, M.,Jean, L.,Kovarik, Z.,Renard, P.Y.; Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.; Chemistry, 24:9675-9691, 2018; PubMed: 29672968; DOI: 10.1002/chem.201801394

Experimental method

X-RAY DIFFRACTION (2.21998854547 Å)