6ESY

Human butyrylcholinesterase in complex with thioflavine T

Summary for 6ESY

• Entry DOI: 10.2210/pdb6esy/pdb
• Related: 6ep4 6eqp 6eqq 6esj
• Descriptor: Cholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: butyrylcholinesterase, inhibitor, complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 124849.45

Authors

Nachon, F.,Brazzolotto, X.,Wandhammer, M.,Trovaslet-Leroy, M.,Macdonald, I.R.,Darvesh, S.,Rosenberry, T.L. (deposition date: 2017-10-24, release date: 2017-12-13, Last modification date: 2024-01-17)

• Primary citation: Rosenberry, T.L.,Brazzolotto, X.,Macdonald, I.R.,Wandhammer, M.,Trovaslet-Leroy, M.,Darvesh, S.,Nachon, F.; Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.; Molecules, 22:-, 2017; PubMed: 29186056; DOI: 10.3390/molecules22122098

Experimental method

X-RAY DIFFRACTION (2.8 Å)