6EQX

X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Arg-Arg-Arg-Val-Arg-Amba

Summary for 6EQX

• Entry DOI: 10.2210/pdb6eqx/pdb
• Descriptor: Furin, Arg-Arg-Arg-Val-Arg-00S, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: protease, inhibitor, proprotein convertase, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Golgi apparatus, trans-Golgi network membrane ; Single- pass type I membrane protein : P09958
• Total number of polymer chains: 2
• Total formula weight: 53513.35

Authors

Dahms, S.O.,Than, M.E. (deposition date: 2017-10-16, release date: 2018-02-28, Last modification date: 2024-01-17)

• Primary citation: Dahms, S.O.,Hardes, K.,Steinmetzer, T.,Than, M.E.; X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.; Biochemistry, 57:925-934, 2018; PubMed: 29314830; DOI: 10.1021/acs.biochem.7b01124

Experimental method

X-RAY DIFFRACTION (1.994 Å)