6EHT

Modulation of PCNA sliding surface by p15PAF suggests a suppressive mechanism for cisplatin-induced DNA lesion bypass by pol eta holoenzyme

Summary for 6EHT

• Entry DOI: 10.2210/pdb6eht/pdb
• Descriptor: Proliferating cell nuclear antigen, PCNA-associated factor, DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), ... (6 entities in total)
• Functional Keywords: structural analysis, human pcna p15 dna macro complex, dna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 7
• Total formula weight: 95174.09

Authors

De March, M.,Barrera-Vilarmau, S.,Mentegari, E.,Merino, N.,Bressan, E.,Maga, G.,Crehuet, R.,Onesti, S.,Blanco, F.J.,De Biasio, A. (deposition date: 2017-09-15, release date: 2018-08-08, Last modification date: 2024-01-17)

• Primary citation: De March, M.,Barrera-Vilarmau, S.,Crespan, E.,Mentegari, E.,Merino, N.,Gonzalez-Magana, A.,Romano-Moreno, M.,Maga, G.,Crehuet, R.,Onesti, S.,Blanco, F.J.,De Biasio, A.; p15PAF binding to PCNA modulates the DNA sliding surface.; Nucleic Acids Res., 46:9816-9828, 2018; PubMed: 30102405; DOI: 10.1093/nar/gky723

Experimental method

X-RAY DIFFRACTION (3.2 Å)