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6EGE

Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor

Summary for 6EGE
Entry DOI10.2210/pdb6ege/pdb
DescriptorInterleukin-1 receptor-associated kinase 4, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide (3 entities in total)
Functional Keywordskinase, unphosphorylated, inactive, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight68191.47
Authors
Ferrao, R.,Liu, Q.,Wu, H. (deposition date: 2018-08-19, release date: 2019-02-13, Last modification date: 2024-03-13)
Primary citationWang, L.,Ferrao, R.,Li, Q.,Hatcher, J.M.,Choi, H.G.,Buhrlage, S.J.,Gray, N.S.,Wu, H.
Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294:4511-4519, 2019
Cited by
PubMed: 30679311
DOI: 10.1074/jbc.RA118.005428
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.401 Å)
Structure validation

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