6EGD

Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor

Summary for 6EGD

DescriptorInterleukin-1 receptor-associated kinase 4, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide (3 entities in total)
Functional Keywordskinase, unphosphorylated, inactive, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight68225.57
Authors
Ferrao, R.,Wu, H. (deposition date: 2018-08-19, release date: 2019-02-13)
Primary citation
Wang, L.,Ferrao, R.,Li, Q.,Hatcher, J.M.,Choi, H.G.,Buhrlage, S.J.,Gray, N.S.,Wu, H.
Conformational flexibility and type II inhibition of IRAK4
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.230110 0.8% 2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6egd
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Molmil generated image of 6egd
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Molmil generated image of 6egd
rotated about y axis by 90°