6EGD
Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor
Summary for 6EGD
| Entry DOI | 10.2210/pdb6egd/pdb |
| Descriptor | Interleukin-1 receptor-associated kinase 4, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide (3 entities in total) |
| Functional Keywords | kinase, unphosphorylated, inactive, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 68225.57 |
| Authors | Ferrao, R.,Wu, H. (deposition date: 2018-08-19, release date: 2019-02-13, Last modification date: 2024-03-13) |
| Primary citation | Wang, L.,Ferrao, R.,Li, Q.,Hatcher, J.M.,Choi, H.G.,Buhrlage, S.J.,Gray, N.S.,Wu, H. Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J.Biol.Chem., 294:4511-4519, 2019 Cited by PubMed: 30679311DOI: 10.1074/jbc.RA118.005428 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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