6EG9
IRAK4 in complex with Ponatinib
Summary for 6EG9
Entry DOI | 10.2210/pdb6eg9/pdb |
Descriptor | Interleukin-1 receptor-associated kinase 4, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 71135.88 |
Authors | |
Primary citation | Wang, L.,Ferrao, R.,Li, Q.,Hatcher, J.M.,Choi, H.G.,Buhrlage, S.J.,Gray, N.S.,Wu, H. Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J.Biol.Chem., 294:4511-4519, 2019 Cited by PubMed: 30679311DOI: 10.1074/jbc.RA118.005428 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.414 Å) |
Structure validation
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