6E43

Crystal structure of human indoleamine 2,3-dioxygenase 1 (IDO1) in complex with a BMS-978587 analog

Summary for 6E43

Entry DOI	10.2210/pdb6e43/pdb
Descriptor	Indoleamine 2,3-dioxygenase 1, (1R,2S)-2-(4-[cyclohexyl(2-methylpropyl)amino]-3-{[(4-methylphenyl)carbamoyl]amino}phenyl)cyclopropane-1-carboxylic acid, BENZOIC ACID, ... (4 entities in total)
Functional Keywords	ido1, bms-978587 analog, inhibitor complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	183546.52
Authors	Luo, S.,Tong, L. (deposition date: 2018-07-16, release date: 2018-11-14, Last modification date: 2024-03-13)
Primary citation	Luo, S.,Xu, K.,Xiang, S.,Chen, J.,Chen, C.,Guo, C.,Tong, Y.,Tong, L. High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallogr F Struct Biol Commun, 74:717-724, 2018 Cited by PubMed: 30387777 DOI: 10.1107/S2053230X18012955 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.705 Å)

Structure validation