6E3U

Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist M1001

Summary for 6E3U

• Entry DOI: 10.2210/pdb6e3u/pdb
• Related: 6E3S 6E3T
• Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[2-(pyrrolidin-1-yl)phenyl]amino}-1H-1lambda~6~,2-benzothiazole-1,1-dione (3 entities in total)
• Functional Keywords: complex, agonist, transcription factor, transcription, transcription-agonist complex, transcription/agonist
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 85921.75

Authors

Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F. (deposition date: 2018-07-15, release date: 2019-02-13, Last modification date: 2023-10-11)

• Primary citation: Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.L.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F.; Bidirectional modulation of HIF-2 activity through chemical ligands.; Nat. Chem. Biol., 15:367-376, 2019; PubMed: 30804532; DOI: 10.1038/s41589-019-0234-5

Experimental method

X-RAY DIFFRACTION (2.85 Å)