6E3T

Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist T1001

Summary for 6E3T

Related6E3S
DescriptorAryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, (6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole (3 entities in total)
Functional Keywordscomplex, antagonist, transcription factor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceMus musculus (Mouse)
Total number of polymer chains2
Total molecular weight85992.67
Authors
Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F. (deposition date: 2018-07-15, release date: 2019-02-13, Last modification date: 2019-03-13)
Primary citation
Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.L.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F.
Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 2019
PubMed: 30804532 (PDB entries with the same primary citation)
DOI: 10.1038/s41589-019-0234-5
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.30835 0.2% 3.9% 2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6e3t
no rotation
Molmil generated image of 6e3t
rotated about x axis by 90°
Molmil generated image of 6e3t
rotated about y axis by 90°