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6E3S

Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385

Summary for 6E3S
Entry DOI10.2210/pdb6e3s/pdb
DescriptorAryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile (3 entities in total)
Functional Keywordscomplex, antagonist, transcription factor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceMus musculus (Mouse)
More
Total number of polymer chains2
Total formula weight85977.69
Authors
Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F. (deposition date: 2018-07-15, release date: 2019-02-13, Last modification date: 2023-10-11)
Primary citationWu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.L.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F.
Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 15:367-376, 2019
Cited by
PubMed: 30804532
DOI: 10.1038/s41589-019-0234-5
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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