6E0Q
The N-terminal domain of PA endonuclease from the influenza H1N1 virus in complex with 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid
Summary for 6E0Q
| Entry DOI | 10.2210/pdb6e0q/pdb |
| Descriptor | Polymerase acidic protein, MANGANESE (II) ION, 4,6-dihydroxy-2-methyl-5-oxocyclohepta-1,3,6-triene-1-carboxylic acid, ... (5 entities in total) |
| Functional Keywords | inhibitor, endonuclease, influenza, pa domain, hydrolase-hydrolase inhibitor complex, viral protein, hydrolase/hydrolase inhibitor |
| Biological source | Influenza A virus |
| Total number of polymer chains | 1 |
| Total formula weight | 22898.83 |
| Authors | Dick, B.L.,Morrison, C.N.,Cohen, S.M. (deposition date: 2018-07-06, release date: 2018-11-07, Last modification date: 2023-10-11) |
| Primary citation | Credille, C.V.,Dick, B.L.,Morrison, C.N.,Stokes, R.W.,Adamek, R.N.,Wu, N.C.,Wilson, I.A.,Cohen, S.M. Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. J. Med. Chem., 61:10206-10217, 2018 Cited by PubMed: 30351002DOI: 10.1021/acs.jmedchem.8b01363 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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