6DZZ

Cryo-EM Structure of the wild-type human serotonin transporter in complex with ibogaine and 15B8 Fab in the inward conformation

Summary for 6DZZ

Entry DOI	10.2210/pdb6dzz/pdb
EMDB information	8943
Descriptor	Sodium-dependent serotonin transporter, 15B8 antibody heavy chain, 15B8 antibody light chain, ... (6 entities in total)
Functional Keywords	ibogaine, human serotonin transporter, fab, transport protein-immune system complex, transport protein/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	87007.12
Authors	Yang, D.,Coleman, J.A.,Gouaux, E. (deposition date: 2018-07-05, release date: 2019-04-24, Last modification date: 2020-07-29)
Primary citation	Coleman, J.A.,Yang, D.,Zhao, Z.,Wen, P.C.,Yoshioka, C.,Tajkhorshid, E.,Gouaux, E. Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Nature, 569:141-145, 2019 Cited by PubMed: 31019304 DOI: 10.1038/s41586-019-1135-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation