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6DYZ

Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((prop-2-yn-1-ylthio)methyl)pyrrolidin-3-ol

Summary for 6DYZ
Entry DOI10.2210/pdb6dyz/pdb
DescriptorS-methyl-5'-thioadenosine phosphorylase, CHLORIDE ION, PHOSPHATE ION, ... (6 entities in total)
Functional Keywordsmtap enzyme, cancer, phosphorylase, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight33788.54
Authors
Harijan, R.K.,Ducati, R.G.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2018-07-02, release date: 2019-03-20, Last modification date: 2023-10-11)
Primary citationHarijan, R.K.,Hoff, O.,Ducati, R.G.,Firestone, R.S.,Hirsch, B.M.,Evans, G.B.,Schramm, V.L.,Tyler, P.C.
Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.
J. Med. Chem., 62:3286-3296, 2019
Cited by
PubMed: 30860833
DOI: 10.1021/acs.jmedchem.8b01642
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.62 Å)
Structure validation

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