6DY7

WDR5 in complex with a WIN site inhibitor

Summary for 6DY7

Entry DOI	10.2210/pdb6dy7/pdb
Descriptor	WD repeat-containing protein 5, N-[3-(2,4-dichlorophenoxy)propyl]-1H-imidazol-2-amine, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	wd40 repeat, epigenetic, wdr5-mll, win site, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33952.37
Authors	Phan, J.,Wang, F.,Fesik, S.W. (deposition date: 2018-07-01, release date: 2019-03-13, Last modification date: 2024-03-13)
Primary citation	Aho, E.R.,Wang, J.,Gogliotti, R.D.,Howard, G.C.,Phan, J.,Acharya, P.,Macdonald, J.D.,Cheng, K.,Lorey, S.L.,Lu, B.,Wenzel, S.,Foshage, A.M.,Alvarado, J.,Wang, F.,Shaw, J.G.,Zhao, B.,Weissmiller, A.M.,Thomas, L.R.,Vakoc, C.R.,Hall, M.D.,Hiebert, S.W.,Liu, Q.,Stauffer, S.R.,Fesik, S.W.,Tansey, W.P. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26:2916-2928.e13, 2019 Cited by PubMed: 30865883 DOI: 10.1016/j.celrep.2019.02.047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation