Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6DXK

Glucocorticoid Receptor in complex with Compound 11

Summary for 6DXK
Entry DOI10.2210/pdb6dxk/pdb
DescriptorGlucocorticoid receptor, (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-(3,3-dimethylbut-1-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (non-preferred name) (3 entities in total)
Functional Keywordssignaling protein, nuclear hormone receptor, ligand complex, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight60277.96
Authors
Primary citationRew, Y.,Du, X.,Eksterowicz, J.,Zhou, H.,Jahchan, N.,Zhu, L.,Yan, X.,Kawai, H.,McGee, L.R.,Medina, J.C.,Huang, T.,Chen, C.,Zavorotinskaya, T.,Sutimantanapi, D.,Waszczuk, J.,Jackson, E.,Huang, E.,Ye, Q.,Fantin, V.R.,Sun, D.
Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).
J. Med. Chem., 61:7767-7784, 2018
Cited by
PubMed: 30091920
DOI: 10.1021/acs.jmedchem.8b00743
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.05 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon