6DUC

Crystal structure of mutant beta-K167T tryptophan synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the alpha-site, cesium ion at the metal coordination site, and 2-aminophenol quinonoid (1D0) at the beta-site

Summary for 6DUC

• Entry DOI: 10.2210/pdb6duc/pdb
• Related: 4HPJ
• Descriptor: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (10 entities in total)
• Functional Keywords: f9f, 1d0, cesium ion, mutant beta-k167t, lyase, lyase inhibitor, 2-aminophenol quinonoid, salmonella typhimurium, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Salmonella typhimurium (Salmonella enterica subsp. enterica serovar Typhimurium); More
• Total number of polymer chains: 2
• Total formula weight: 73918.97

Authors

Hilario, E.,Dunn, M.F.,Mueller, L.J.,Fan, L. (deposition date: 2018-06-20, release date: 2019-06-26, Last modification date: 2023-10-11)

• Primary citation: Hilario, E.,Dunn, M.F.,Mueller, L.J.,Fan, L.; Tryptophan synthase Q114A mutant in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the alpha-site, aminoacrylate (P1T) at the beta site, and cesium ion at the metal coordination site.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.791 Å)