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6DNA

Crystal structure of T110A mutant human Glutamate oxaloacetate transaminase 1 (GOT1)

Summary for 6DNA
Entry DOI10.2210/pdb6dna/pdb
DescriptorAspartate aminotransferase, cytoplasmic, TETRAETHYLENE GLYCOL, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
Functional Keywordsaspartate aminotransferase, glutamate oxaloacetate transaminase 1, got1, plp, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains6
Total formula weight276779.75
Authors
Assar, Z.,Holt, M.C.,Stein, A.J.,Lairson, L.,Lyssiotis, C.A. (deposition date: 2018-06-06, release date: 2018-11-14, Last modification date: 2023-10-11)
Primary citationHolt, M.C.,Assar, Z.,Beheshti Zavareh, R.,Lin, L.,Anglin, J.,Mashadova, O.,Haldar, D.,Mullarky, E.,Kremer, D.M.,Cantley, L.C.,Kimmelman, A.C.,Stein, A.J.,Lairson, L.L.,Lyssiotis, C.A.
Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry, 57:6604-6614, 2018
Cited by
PubMed: 30365304
DOI: 10.1021/acs.biochem.8b00914
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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