6DCN

Bcl-xL complex with Beclin 1 BH3 domain T108pThr

Replaces:  5VB1

Summary for 6DCN

• Entry DOI: 10.2210/pdb6dcn/pdb
• Related: 5VAU 5VAX 5VAY
• Descriptor: BCL-xl protein, Beclin-1 (3 entities in total)
• Functional Keywords: apoptosis, bcl-2, autophagy, beclin 1
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 41257.78

Authors

Lee, E.F.,Smith, B.J.,Smith, N.A.,Yao, S.,Fairlie, W.D. (deposition date: 2018-05-07, release date: 2018-05-23, Last modification date: 2023-10-11)

• Primary citation: Lee, E.F.,Smith, N.A.,Soares da Costa, T.P.,Meftahi, N.,Yao, S.,Harris, T.J.,Tran, S.,Pettikiriarachchi, A.,Perugini, M.A.,Keizer, D.W.,Evangelista, M.,Smith, B.J.,Fairlie, W.D.; Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.; Autophagy, 15:785-795, 2019; PubMed: 30626284; DOI: 10.1080/15548627.2018.1564557

Experimental method

X-RAY DIFFRACTION (2.444 Å)