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6D56

Ras:SOS:Ras in complex with a small molecule activator

Summary for 6D56
Entry DOI10.2210/pdb6d56/pdb
DescriptorGTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total)
Functional Keywordsras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight95886.99
Authors
Phan, J.,Hodges, T.,Fesik, S.W. (deposition date: 2018-04-19, release date: 2018-09-19, Last modification date: 2023-11-15)
Primary citationHodges, T.R.,Abbott, J.R.,Little, A.J.,Sarkar, D.,Salovich, J.M.,Howes, J.E.,Akan, D.T.,Sai, J.,Arnold, A.L.,Browning, C.,Burns, M.C.,Sobolik, T.,Sun, Q.,Beesetty, Y.,Coker, J.A.,Scharn, D.,Stadtmueller, H.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,McConnell, D.B.,Fesik, S.W.
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J. Med. Chem., 61:8875-8894, 2018
Cited by
PubMed: 30205005
DOI: 10.1021/acs.jmedchem.8b01108
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.68 Å)
Structure validation

217705

數據於2024-03-27公開中

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