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6D2P

Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A

Summary for 6D2P
Entry DOI10.2210/pdb6d2p/pdb
DescriptorGermline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, IOMAclass naive CLK31 Fab heavy chain, IOMAclass naive CLK31 Fab light chain, ... (5 entities in total)
Functional Keywordshiv-1 gp120, engineered outer domain (eod), germline targeting, cd4 binding site, ioma-class naive human germline antibody, immune system, viral-protein complex, healthy hiv-1 negative donor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight66465.18
Authors
Sarkar, A.,Wilson, I.A. (deposition date: 2018-04-13, release date: 2019-01-16, Last modification date: 2023-10-04)
Primary citationHavenar-Daughton, C.,Sarkar, A.,Kulp, D.W.,Toy, L.,Hu, X.,Deresa, I.,Kalyuzhniy, O.,Kaushik, K.,Upadhyay, A.A.,Menis, S.,Landais, E.,Cao, L.,Diedrich, J.K.,Kumar, S.,Schiffner, T.,Reiss, S.M.,Seumois, G.,Yates, J.R.,Paulson, J.C.,Bosinger, S.E.,Wilson, I.A.,Schief, W.R.,Crotty, S.
The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.
Sci Transl Med, 10:-, 2018
Cited by
PubMed: 29973404
DOI: 10.1126/scitranslmed.aat0381
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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