E. coli DHFR substrate complex with Dihydrofolate

Summary for 6CXK

Related6CW7 6CQA
DescriptorDihydrofolate reductase, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywordsdhfr, dihydrofolate reductase, dihydrofolate, complex, oxidoreductase
Biological sourceEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Total number of polymer chains1
Total molecular weight19521.53
Cao, H.,Rodrigues, J.,Benach, J.,Frommelt, A.,Morisco, L.,Koss, J.,Shakhnovich, E.,Skolnick, J. (deposition date: 2018-04-03, release date: 2019-01-09)
Primary citation
Cao, H.,Gao, M.,Zhou, H.,Skolnick, J.
The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release.
Commun Biol, 1:226-226, 2018
PubMed: 30564747 (PDB entries with the same primary citation)
DOI: 10.1038/s42003-018-0236-y
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.196100 7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6cxk
no rotation
Molmil generated image of 6cxk
rotated about x axis by 90°
Molmil generated image of 6cxk
rotated about y axis by 90°
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan