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6CWY

Crystal structure of SUMO E1 in complex with an allosteric inhibitor

Summary for 6CWY
Entry DOI10.2210/pdb6cwy/pdb
DescriptorSUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, GLYCEROL, ... (8 entities in total)
Functional Keywordsrossmann-like fold, ubiquitin-like fold, ubiquitin activating enzyme, activity, atp binding, ligase activity, atp/mg binding, ubiquitin e2, ligase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
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Total number of polymer chains2
Total formula weight113065.32
Authors
Lv, Z.,Yuan, L.,Atkison, J.H.,Williams, K.M.,Olsen, S.K. (deposition date: 2018-04-01, release date: 2019-01-16, Last modification date: 2023-10-04)
Primary citationLv, Z.,Yuan, L.,Atkison, J.H.,Williams, K.M.,Vega, R.,Sessions, E.H.,Divlianska, D.B.,Davies, C.,Chen, Y.,Olsen, S.K.
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9:5145-5145, 2018
Cited by
PubMed: 30514846
DOI: 10.1038/s41467-018-07015-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.462 Å)
Structure validation

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