Crystal structure of SUMO E1 in complex with an allosteric inhibitor

Summary for 6CWY

DescriptorSUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, GLYCEROL, ... (8 entities in total)
Functional Keywordsrossmann-like fold, ubiquitin-like fold, ubiquitin activating enzyme, activity, atp binding, ligase activity, atp/mg binding, ubiquitin e2, ligase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight113065.32
Lv, Z.,Yuan, L.,Atkison, J.H.,Williams, K.M.,Olsen, S.K. (deposition date: 2018-04-01, release date: 2019-01-16)
Primary citation
Lv, Z.,Yuan, L.,Atkison, J.H.,Williams, K.M.,Vega, R.,Sessions, E.H.,Divlianska, D.B.,Davies, C.,Chen, Y.,Olsen, S.K.
Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9:5145-5145, 2018
PubMed: 30514846 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-07015-1
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2373 0.1% 1.3% 7.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6cwy
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Molmil generated image of 6cwy
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Molmil generated image of 6cwy
rotated about y axis by 90°
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