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6CTU

Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CFCL, beta, gamma dCTP analogue

Summary for 6CTU
Entry DOI10.2210/pdb6ctu/pdb
DescriptorDNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(2DA))-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... (10 entities in total)
Functional Keywordsdna polymerase beta, conformational change, enzyme mechanism, lfer, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight48710.81
Authors
Batra, V.K.,Wilson, S.H. (deposition date: 2018-03-23, release date: 2018-06-20, Last modification date: 2023-10-04)
Primary citationBatra, V.K.,Oertell, K.,Beard, W.A.,Kashemirov, B.A.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H.
Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.
Biochemistry, 57:3934-3944, 2018
Cited by
PubMed: 29874056
DOI: 10.1021/acs.biochem.8b00418
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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