6CRN

Structure of the USP15 deubiquitinase domain in complex with a high-affinity first-generation Ubv

Summary for 6CRN

• Entry DOI: 10.2210/pdb6crn/pdb
• Related: 6CPM 6CSI
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.2, ZINC ION, ... (4 entities in total)
• Functional Keywords: deubiuqitination, ubv, high-affinity, inhibition, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 200396.50

Authors

Singer, A.U.,Teyra, J.,Boehmelt, G.,Lenter, M.,Sicheri, F.,Sidhu, S.S. (deposition date: 2018-03-19, release date: 2019-01-23, Last modification date: 2023-10-04)

• Primary citation: Teyra, J.,Singer, A.U.,Schmitges, F.W.,Jaynes, P.,Kit Leng Lui, S.,Polyak, M.J.,Fodil, N.,Krieger, J.R.,Tong, J.,Schwerdtfeger, C.,Brasher, B.B.,Ceccarelli, D.F.J.,Moffat, J.,Sicheri, F.,Moran, M.F.,Gros, P.,Eichhorn, P.J.A.,Lenter, M.,Boehmelt, G.,Sidhu, S.S.; Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.; Structure, 27:590-, 2019; PubMed: 30713027; DOI: 10.1016/j.str.2019.01.002

Experimental method

X-RAY DIFFRACTION (2.5 Å)