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6CMP

Closed structure of inactive SHP2 mutant C459E

Summary for 6CMP
Entry DOI10.2210/pdb6cmp/pdb
DescriptorTyrosine-protein phosphatase non-receptor type 11 (2 entities in total)
Functional Keywordsprotein tyrosine phosphatase, src homology domain 2, inactive state, inactive mutant, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight122061.58
Authors
Padua, R.A.P.,Sun, Y.,Marko, I.,Pitsawong, W.,Kern, D. (deposition date: 2018-03-06, release date: 2018-11-14, Last modification date: 2023-10-04)
Primary citationPadua, R.A.P.,Sun, Y.,Marko, I.,Pitsawong, W.,Stiller, J.B.,Otten, R.,Kern, D.
Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2.
Nat Commun, 9:4507-4507, 2018
Cited by
PubMed: 30375376
DOI: 10.1038/s41467-018-06814-w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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