6CM2

SAMHD1 HD domain bound to decitabine triphosphate

Summary for 6CM2

DescriptorDeoxynucleoside triphosphate triphosphohydrolase SAMHD1, 6-amino-3-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-erythro-pentofuranosyl}-3,4-dihydro-1,3,5-triazin-2(1H)-one, GUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywordssamhd1, analogues, decitabine, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight244367.92
Authors
Primary citation
Oellerich, T.,Schneider, C.,Thomas, D.,Knecht, K.M.,Buzovetsky, O.,Kaderali, L.,Schliemann, C.,Bohnenberger, H.,Angenendt, L.,Hartmann, W.,Wardelmann, E.,Rothenburger, T.,Mohr, S.,Scheich, S.,Comoglio, F.,Wilke, A.,Strobel, P.,Serve, H.,Michaelis, M.,Ferreiros, N.,Geisslinger, G.,Xiong, Y.,Keppler, O.T.,Cinatl, J.
SAMHD1 is a Resistance Factor and Predictive Biomarker for Decitabine in Acute Myeloid Leukemia
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.14 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2291 0.1% 3.7% 2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report