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6CM2

SAMHD1 HD domain bound to decitabine triphosphate

Summary for 6CM2
Entry DOI10.2210/pdb6cm2/pdb
DescriptorDeoxynucleoside triphosphate triphosphohydrolase SAMHD1, 6-amino-3-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-erythro-pentofuranosyl}-3,4-dihydro-1,3,5-triazin-2(1H)-one, GUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywordssamhd1, analogues, decitabine, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight244367.92
Authors
Primary citationOellerich, T.,Schneider, C.,Thomas, D.,Knecht, K.M.,Buzovetsky, O.,Kaderali, L.,Schliemann, C.,Bohnenberger, H.,Angenendt, L.,Hartmann, W.,Wardelmann, E.,Rothenburger, T.,Mohr, S.,Scheich, S.,Comoglio, F.,Wilke, A.,Strobel, P.,Serve, H.,Michaelis, M.,Ferreiros, N.,Geisslinger, G.,Xiong, Y.,Keppler, O.T.,Cinatl Jr., J.
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
Nat Commun, 10:3475-3475, 2019
Cited by
PubMed: 31375673
DOI: 10.1038/s41467-019-11413-4
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.14 Å)
Structure validation

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