6CJC

CRYSTAL STRUCTURE OF A FC FRAGMENT LALA MUTANT (L234A, L235A) OF HUMAN IGG1 (CRYSTAL FORM 3)

6CJC の概要

• エントリーDOI: 10.2210/pdb6cjc/pdb
• 分子名称: Uncharacterized protein DKFZp686C11235, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: immunoglobulin, igg1, immune system, immunoglobulin-like beta sandwich, fc fragment, lala mutation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51260.74

構造登録者

Tolbert, W.D.,Van, V.,Pazgier, M. (登録日: 2018-02-26, 公開日: 2019-03-06, 最終更新日: 2023-10-04)

• 主引用文献: Orlandi, C.,Deredge, D.,Ray, K.,Gohain, N.,Tolbert, W.,DeVico, A.L.,Wintrode, P.,Pazgier, M.,Lewis, G.K.; Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fc gamma Receptor Binding.; Structure, 28:516-527.e5, 2020; PubMed: 32209433; DOI: 10.1016/j.str.2020.03.001

実験手法

X-RAY DIFFRACTION (2.575 Å)