6CF7

Crystal structure of the A/Solomon Islands/3/2006(H1N1) influenza virus hemagglutinin in complex with small molecule JNJ4796

Summary for 6CF7

DescriptorHemagglutinin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ... (7 entities in total)
Functional Keywordsglycoprotein, ectodomain, n-glycosylation, viral protein
Biological sourceInfluenza A virus (A/Solomon Islands/3/2006(H1N1))
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Total number of polymer chains2
Total molecular weight59448.88
Authors
Kadam, R.U.,Wilson, I.A. (deposition date: 2018-02-13, release date: 2019-02-13, Last modification date: 2019-03-13)
Primary citation
Dongen, M.J.P.,Kadam, R.U.,Juraszek, J.,Lawson, E.,Brandenburg, B.,Schmitz, F.,Schepens, W.,Stoops, B.,Diepen, H.A.V.,Jongeneelen, M.,Tang, C.,Vermont, J.,Real, A.V.E.O.,Blokland, S.,Garg, D.,Wu, W.,Goutier, W.,Klap, J.M.,Peeters, D.C.G.,Wu, J.,Buck, C.,Jonckers, T.H.M.,Roevens, P.,Vogels, R.,Koudstaal, W.,Friesen, R.H.E.,Raboisson, P.,Dhanak, D.,Goudsmit, J.,Wilson, I.A.
A small-molecule fusion inhibitor of influenza virus is orally active in mice
Science, 2019
DOI: 10.1126/science.aar6221
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.719 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2473 0.2% 1.9% 4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6cf7
no rotation
Molmil generated image of 6cf7
rotated about x axis by 90°
Molmil generated image of 6cf7
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 6cf7
no rotation
Molmil generated image of 6cf7
rotated about x axis by 90°
Molmil generated image of 6cf7
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6cf7.pdb1.gz [530.52 KB])