6CDX

High-resolution crystal structure of fluoropropylated cystine knot, binding to alpha-5 beta-6 integrin

Summary for 6CDX

• Entry DOI: 10.2210/pdb6cdx/pdb
• Related: 2N8B 2N8C
• Descriptor: cystine knot (fluoropropylated) (2 entities in total)
• Functional Keywords: cysteine, disulfides, alpha-5 beta-6 integrin binding epitope, cancer imaging, protein binding
• Biological source: Momordica cochinchinensis (Spiny bitter cucumber); More
• Total number of polymer chains: 2
• Total formula weight: 7833.00

Authors

Kimura, R.,Nix, J.,Bongura, C.,Chakraborti, S.,Gambhir, S.,Filipp, F.V. (deposition date: 2018-02-09, release date: 2019-08-14, Last modification date: 2023-10-04)

• Primary citation: Kimura, R.H.,Wang, L.,Shen, B.,Huo, L.,Tummers, W.,Filipp, F.V.,Guo, H.H.,Haywood, T.,Abou-Elkacem, L.,Baratto, L.,Habte, F.,Devulapally, R.,Witney, T.H.,Cheng, Y.,Tikole, S.,Chakraborti, S.,Nix, J.,Bonagura, C.A.,Hatami, N.,Mooney, J.J.,Desai, T.,Turner, S.,Gaster, R.S.,Otte, A.,Visser, B.C.,Poultsides, G.A.,Norton, J.,Park, W.,Stolowitz, M.,Lau, K.,Yang, E.,Natarajan, A.,Ilovich, O.,Srinivas, S.,Srinivasan, A.,Paulmurugan, R.,Willmann, J.,Chin, F.T.,Cheng, Z.,Iagaru, A.,Li, F.,Gambhir, S.S.; Evaluation of integrin alpha v beta6cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis.; Nat Commun, 10:4673-4673, 2019; PubMed: 31611594; DOI: 10.1038/s41467-019-11863-w

Experimental method

X-RAY DIFFRACTION (1 Å)