6CDT

Structure of Human Anaplastic Lymphoma Kinase Domain

Summary for 6CDT

• Entry DOI: 10.2210/pdb6cdt/pdb
• Descriptor: ALK tyrosine kinase receptor (2 entities in total)
• Functional Keywords: kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 36909.36

Authors

McTigue, M.,Deng, Y.L.,Liu, W.,Brooun, A. (deposition date: 2018-02-09, release date: 2019-02-20, Last modification date: 2023-10-04)

• Primary citation: Johnson, T.W.,Bolanos, B.,Brooun, A.,Gallego, R.A.,Gehlhaar, D.,Jalaie, M.,McTigue, M.,Timofeevski, S.; Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase.; ACS Med Chem Lett, 9:872-877, 2018; PubMed: 30258533; DOI: 10.1021/acsmedchemlett.8b00348

Experimental method

X-RAY DIFFRACTION (1.8 Å)