6C8C
Chimeric Pol kappa RIR Rev1 C-terminal domain in complex with JHRE06
Summary for 6C8C
| Entry DOI | 10.2210/pdb6c8c/pdb |
| Descriptor | Chimeric protein of the Pol Kappa RIR helix and the Rev1 C-terminal domain, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one (3 entities in total) |
| Functional Keywords | translesion synthesis, dna damage tolerance, rev1, replication |
| Biological source | Mus musculus (Mouse) More |
| Total number of polymer chains | 2 |
| Total formula weight | 28004.39 |
| Authors | Najeeb, J.,Zhou, P. (deposition date: 2018-01-24, release date: 2019-06-12, Last modification date: 2023-10-04) |
| Primary citation | Wojtaszek, J.L.,Chatterjee, N.,Najeeb, J.,Ramos, A.,Lee, M.,Bian, K.,Xue, J.Y.,Fenton, B.A.,Park, H.,Li, D.,Hemann, M.T.,Hong, J.,Walker, G.C.,Zhou, P. A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. Cell, 178:152-, 2019 Cited by PubMed: 31178121DOI: 10.1016/j.cell.2019.05.028 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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