6C1O

FGFR1 kinase domain complexed with FIIN-1

Summary for 6C1O

• Entry DOI: 10.2210/pdb6c1o/pdb
• Descriptor: Fibroblast growth factor receptor 1, N-(3-{[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-{[4-(diethylamino)butyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)prop-2-enamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 72116.49

Authors

Kalyukina, M.,Yosaatmadja, Y.,Smaill, J.B.,Squire, C.J. (deposition date: 2018-01-05, release date: 2019-01-16, Last modification date: 2023-10-04)

• Primary citation: Kalyukina, M.,Yosaatmadja, Y.,Patterson, A.V.,Smaill, J.B.,Squire, C.J.; A new class of FGFR1 inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.29 Å)