6C1O

FGFR1 kinase domain complexed with FIIN-1

Summary for 6C1O

DescriptorFibroblast growth factor receptor 1, N-(3-{[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-{[4-(diethylamino)butyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)prop-2-enamide, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight72116.5
Authors
Kalyukina, M.,Yosaatmadja, Y.,Smaill, J.B.,Squire, C.J. (deposition date: 2018-01-05, release date: 2019-01-16)
Primary citation
Kalyukina, M.,Yosaatmadja, Y.,Patterson, A.V.,Smaill, J.B.,Squire, C.J.
A new class of FGFR1 inhibitors
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.29 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27700 0.2% 1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6c1o
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Molmil generated image of 6c1o
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Molmil generated image of 6c1o
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More Biological unit images

Molmil generated image of 6c1o
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Molmil generated image of 6c1o
rotated about x axis by 90°
Molmil generated image of 6c1o
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6c1o.pdb1.gz [92.46 KB])
Coordinate files for Biological unit (6c1o.pdb2.gz [85.33 KB])
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