6C18

FGFR1 kinase complex with inhibitor SN37115

Summary for 6C18

• Entry DOI: 10.2210/pdb6c18/pdb
• Related: 5UOK 5UOM 5UON
• Descriptor: Fibroblast growth factor receptor 1, 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-[(propan-2-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 71988.32

Authors

Yosaatmadja, Y.,Smaill, J.B.,Squire, C.J. (deposition date: 2018-01-04, release date: 2019-01-16, Last modification date: 2023-10-04)

• Primary citation: Yosaatmadja, Y.,Squire, C.J.,Patterson, A.V.,Smaill, J.B.; Understanding the structural requirements for covalent inhibition of FGFR1-3; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)