6BZ1

MEF2 Chimera D83V mutant/DNA complex

Summary for 6BZ1

• Entry DOI: 10.2210/pdb6bz1/pdb
• Descriptor: MEF2 CHIMERA, DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(P*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3') (3 entities in total)
• Functional Keywords: mef2, transcription factor, d83v mutant, conformation switch, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 63028.56

Authors

Lei, X.,Chen, L. (deposition date: 2017-12-21, release date: 2018-02-07, Last modification date: 2024-03-13)

• Primary citation: Lei, X.,Kou, Y.,Fu, Y.,Rajashekar, N.,Shi, H.,Wu, F.,Xu, J.,Luo, Y.,Chen, L.; The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.; J. Mol. Biol., 430:1157-1172, 2018; PubMed: 29477338; DOI: 10.1016/j.jmb.2018.02.012

Experimental method

X-RAY DIFFRACTION (2.97 Å)