6BW6

Human GPT (DPAGT1) H129 variant in complex with tunicamycin

Summary for 6BW6

Entry DOI	10.2210/pdb6bw6/pdb
Descriptor	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, Tunicamycin, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate (3 entities in total)
Functional Keywords	n-linked glycosylation, endoplasmic reticulum, tunicamycin, natural product, transferase, transferase-antibiotic complex, transferase/antibiotic
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	195071.15
Authors	Yoo, J.,Kuk, A.C.Y.,Mashalidis, E.H.,Lee, S.-Y. (deposition date: 2017-12-14, release date: 2018-02-21, Last modification date: 2023-10-04)
Primary citation	Yoo, J.,Mashalidis, E.H.,Kuk, A.C.Y.,Yamamoto, K.,Kaeser, B.,Ichikawa, S.,Lee, S.Y. GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation. Nat. Struct. Mol. Biol., 25:217-224, 2018 Cited by PubMed: 29459785 DOI: 10.1038/s41594-018-0031-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation