6BR1

Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a

Summary for 6BR1

Entry DOI	10.2210/pdb6br1/pdb
Descriptor	Tubulin alpha-1B chain, 2-chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)pyrido[2,3-d]pyrimidine, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywords	microtubule inhibitor, colchicine cancer, cell cycle, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	264964.36
Authors	Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2017-11-29, release date: 2018-06-27, Last modification date: 2024-03-13)
Primary citation	Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D. Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy. J. Med. Chem., 61:1704-1718, 2018 Cited by PubMed: 29406710 DOI: 10.1021/acs.jmedchem.7b01858 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.304 Å)

Structure validation