6BQH

Crystal structure of 5-HT2C in complex with ritanserin

Summary for 6BQH

• Entry DOI: 10.2210/pdb6bqh/pdb
• Descriptor: 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total)
• Functional Keywords: human 5-ht2c receptor, gpcr, ritanserin, selectivity, bril, lcp, membrane protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P28335
• Total number of polymer chains: 1
• Total formula weight: 54597.91

Authors

Peng, Y.,McCorvy, J.D.,Harpsoe, K.,Lansu, K.,Yuan, S.,Popov, P.,Qu, L.,Pu, M.,Che, T.,Nikolajse, L.F.,Huang, X.P.,Wu, Y.,Shen, L.,Bjorn-Yoshimoto, W.E.,Ding, K.,Wacker, D.,Han, G.W.,Cheng, J.,Katritch, V.,Jensen, A.A.,Hanson, M.A.,Zhao, S.,Gloriam, D.E.,Roth, B.L.,Stevens, R.C.,Liu, Z. (deposition date: 2017-11-27, release date: 2018-02-14, Last modification date: 2023-10-04)

• Primary citation: Peng, Y.,McCorvy, J.D.,Harpsoe, K.,Lansu, K.,Yuan, S.,Popov, P.,Qu, L.,Pu, M.,Che, T.,Nikolajsen, L.F.,Huang, X.P.,Wu, Y.,Shen, L.,Bjorn-Yoshimoto, W.E.,Ding, K.,Wacker, D.,Han, G.W.,Cheng, J.,Katritch, V.,Jensen, A.A.,Hanson, M.A.,Zhao, S.,Gloriam, D.E.,Roth, B.L.,Stevens, R.C.,Liu, Z.J.; 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.; Cell, 172:719-730.e14, 2018; PubMed: 29398112; DOI: 10.1016/j.cell.2018.01.001

Experimental method

X-RAY DIFFRACTION (2.7 Å)