6BQG

Crystal structure of 5-HT2C in complex with ergotamine

Summary for 6BQG

Entry DOI	10.2210/pdb6bqg/pdb
Descriptor	5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, Ergotamine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate (3 entities in total)
Functional Keywords	human 5-ht2c receptor, gpcr, ergotamine, polypharmacology, bril, lcp, membrane protein
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane ; Multi-pass membrane protein : P28335
Total number of polymer chains	1
Total formula weight	52248.26
Authors	Peng, Y.,McCorvy, J.D.,Harpsoe, K.,Lansu, K.,Yuan, S.,Popov, P.,Qu, L.,Pu, M.,Che, T.,Nikolajse, L.F.,Huang, X.P.,Wu, Y.,Shen, L.,Bjorn-Yoshimoto, W.E.,Ding, K.,Wacker, D.,Han, G.W.,Cheng, J.,Katritch, V.,Jensen, A.A.,Hanson, M.A.,Zhao, S.,Gloriam, D.E.,Roth, B.L.,Stevens, R.C.,Liu, Z. (deposition date: 2017-11-27, release date: 2018-02-14, Last modification date: 2023-10-04)
Primary citation	Peng, Y.,McCorvy, J.D.,Harpsoe, K.,Lansu, K.,Yuan, S.,Popov, P.,Qu, L.,Pu, M.,Che, T.,Nikolajsen, L.F.,Huang, X.P.,Wu, Y.,Shen, L.,Bjorn-Yoshimoto, W.E.,Ding, K.,Wacker, D.,Han, G.W.,Cheng, J.,Katritch, V.,Jensen, A.A.,Hanson, M.A.,Zhao, S.,Gloriam, D.E.,Roth, B.L.,Stevens, R.C.,Liu, Z.J. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell, 172:719-730.e14, 2018 Cited by PubMed: 29398112 DOI: 10.1016/j.cell.2018.01.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation